美国辉瑞公司(Pfizer Inc)博士后职位

Org Marketing Statement

Pfizer Inc: Working together for a healthier world

Founded in 1849, Pfizer is the world’s premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

Job Focus

Pfizer Global Biotherapeutic Technologies is seeking a highly motivated Postdoctoral Research Fellow with extensive expertise in cell biology and associated techniques, to work in a well established Antibody Engineering group. The successful candidate will execute a research project focusing on understanding the biology of tumor receptor internalization and re-cycling. This will involve dissecting the role of antibody target affinity, kinetics and recognition epitope in the process of receptor mediated endocytic antibody internalization, recycling and trafficking to the lysozomal compartment.

Responsibilities

The ideal candidate will use fluorescence techniques and confocal microscopy to investigate and quantify antibody internalization, recycling and lysosomal accumulation/degredation in cancer cells. This will involve antibody generation, conjugation to fluorescent dyes, biophysical analyses (surface plasmon resonance), immunofluorescent assay development using quantitative confocal microscopy techniques and/or high content imaging. The candidate will be expected to publish in high quality journals, perform at a highly collaborative level and present their work at appropriate conferences.

Qualifications

A PhD in Cell Biology or related area/discipline covering immunofluorescence and confocal microscopy analyses is required along with 0-3 years post-doctoral experience with a similar experimental/technique focus. Experience in quantitative immunofluorescent assay development is required. Additional experience/knowledge in antibody immunology, function and engineering/therapeutics and/or cancer biology is desirable. Publication of at least 1 first-author paper in a high impact journal is also a required.

- Significant experience in immunofluorescence confocal microscopy . Experienced in analysing receptor recycling and trafficking to the lysozome.

- Significant experience in cell culture and mammalian protein expression (HEK/CHO/COS cells and cancer lines)

- Cell based assays experience required. Cell kill assay experience.

- FACS (required, up to 2/3-colour FACS)

- BIAcore/surface plasmon resonance

- Antibody Phage Display

- Molecular Biology (PCR, SDM, Ligations, Phage Libraries)

- Chemical conjugations (Amine, thiol coupling or other chemistries)

- Demonstrated with 1st Author publications and presentations at conferences

Equal Employment Opportunity

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business
discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague’s long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer’s support of a colleague’s temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the “at-will” employment relationship between the colleague and Pfizer.

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