牛津大学分子神经退化实验室招收博士后

Laboratory of Molecular Neurodegeneration
University of Oxford
Department of Physiology, Anatomy and Genetics

Postdoctoral Research Assistant
Fixed term post on grade 7: £ 29,249 to £ 31,020
(Starting point on points 1 to 3 of the scale, depending on experience)

“Developing novel BAC transgenic mice of C9ORF72-linked motoneuron disease to study RNA cellular pathways”

Applications are invited for a Postdoctoral Research Assistant to join the Laboratory of Molecular Neurodegeneration, a multidisciplinary laboratory focused on elucidating the molecular mechanisms of neurodegenerative diseases.

The project will investigate the function and dysfunction of the newly discovered gene C9ORF72 causing motorneuron disease (MND) and frontotemporal lobar degeneration (FTLD). First, we will develop a transgenic mouse model carrying a novel C9ORF72 bacterial artificial chromosome (BAC) expression construct to visualize alterations in RNA dynamics and will characterize early-stage molecular, histological and behavioral changes. Second, we will model in vitro the development of molecular pathology in human motoneurons derived from induced pluripotent stem cells (iPS) carrying wild-type or mutant variants of the human C9ORF72 gene and by genome editing using zinc finger nucleases in iPS-derived human motorneurons.

The project will be supervised by Dr Javier Alegre-Abarrategui in Dr Richard Wade-Martins’ Molecular Neurodegeneration Laboratory in collaboration with Prof Kevin Talbot. Together, our laboratories integrate studies of neuropathology, genetics and cell biology to study common molecular mechanisms of neurodegeneration.

Applicants must have a PhD/DPhil or equivalent in a relevant area of research and experience in molecular and cellular neuroscience. The appointment is funded by Motor Neurone Disease Association and is offered for up to 36 months, to start as soon as possible. Informal enquiries may be directed to Dr Alegre-Abarrategui (javier.alegre@dpag.ox.ac.uk) or Dr Wade-Martins (richard-wade-martins@dpag.ox.ac.uk). Further particulars and details of how to apply are available at www.dpag.ox.ac.uk/job_opportunities or email reference@dpag.ox.ac.uk.

The closing date for applications is midday 24th September 2012. Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and selection criteria, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=104151