英国剑桥圣格研究所招收计算机基因组学博士后

The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.

A postdoctoral position is available in Computational Genomics at the Wellcome Trust Sanger Institute under the leadership of Dr Daniel Gaffney. The project is part of a new scientific program at the Sanger Institute in stem cells and cellular phenotyping. The objective of this initiative is to create and genomically characterize a large number of human induced pluripotent stem cells (hIPSCs), with the goal of developing these cells as a model system to understand the functional consequences of human genetic variation. The goal of this project is to understand how genetic variation impacts chromatin structure and transcription in pluripotent and differentiated cell lineages. The post-holder will develop computational and statistical methods to analyse next generation sequencing data generated in our own lab from a variety of high throughput assays including RNA-seq, ChIP-seq, DNaseI-seq and FAIRE-seq.

We welcome candidates with a background in Biology and strong quantitative skills. Candidates from Physics, Statistics or Computer Science with strong interests in computational biology and/or population genetics are also encouraged to apply. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential. We also have our own wet-lab facilities and personnel – as part of their research, the successful candidate will also have the opportunity to work directly with wet- lab staff, generate novel high-throughput data sets and to test hypotheses in an experimental setting. For more information see:

http://www.sanger.ac.uk/research/projects/populationevolution/

Essential Skills

PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Computer Science, Physics)

Excellent programming skills (C, C++, Perl, Python, Java)

Extensive experience of UNIX/Linux and cluster computing

Strong statistical and quantitative skills

Familiarity with statistical modeling and software

Strong publishing record

Ability to communicate ideas and results effectively

Ability to work well with other team members

Ability to work to tight deadlines

Ideal Skills

Experience with analysis of -omics data sets

Previous experience with genetics of gene regulation, QTL analysis

Previous experience with stem cells

Some laboratory experience of genomics assays (ChIP, DNaseI, FAIRE) would be advantageous

Other information

The ultimate goal of our lab is to be able to predict the impact of new mutations on gene regulation and to understand how such changes impact phenotype. To achieve this, we combine of sequence and genome analysis, comparative genomics and population level, expression QTL-mapping. The Sanger Centre offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics. As such, we are in a prime position to begin to address some of these fundamental questions.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award. This position is initially for a fixed term of 3 years. For further information please contact Daniel Gaffney on dg13@sanger.ac.uk.

Benefits
The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk,

To submit your CV and apply for this job please go to https://jobs.sanger.ac.uk, to register and apply on line.

http://twitter.com/sangerinstjobs/